journal6 ›› 2009, Vol. 30 ›› Issue (5): 96-100.

• Chemistry and chemical engineering • Previous Articles     Next Articles

Synthesis of Antimicrobial Pazufloxacin Mesilate


  1. (1.Party Committee Propaganda Department,Jishou University,Jishou 416000,Hunan China;2.Department of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,Hunan China)
  • Online:2009-09-25 Published:2012-04-21

Abstract: 〗Pazufloxacin mesilate was synthesized from (S)-9,10-difluoro-3-methly-7-oxo-2,3-dihydro-7-H-pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylate with nuclephilic substitution,selective decarboxylation,cyclic addition,hydrolysis,Hofmann recomposition and salt formation.The product was tested by HPLC and the results showed content of 91.352 g/L.The optimized process is suitable for industrial mass production.

Key words: antimicrobial, pazufloxacin mesilate, synthesis

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