journal6 ›› 2014, Vol. 35 ›› Issue (1): 63-67.DOI: 10.3969/j.issn.1007-2985.2014.01.015

• Chemistry and chemical engineering • Previous Articles     Next Articles

Synthesis and Conformation of  Maleopimaric Acid Diimide

WANG  Heng-Shan, LI  Jian-Fei, QIN  Jian-Mei, ZHU  Yong-Tao, YE  Man-Yi, LI  Ya-Jun, YAO  Gui-Yang   

  1. (Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry & Pharmacy of Guangxi Normal University,Guilin 541004,Guangxi China)
  • Online:2014-01-25 Published:2014-01-25

Abstract: Maleopimaric acid (compound 2) was formed by Diels-Alder addition of maleic acid anhydride to resin acid,then maleopimaric acid methyl ester (compound 3) was prepared by esterification of dimethyl sulfate.After maleopimaric acid methyl ester interacting with 5-Aminoisoquinoline,the N-aryl methyl maleopimaric acid diimides (compound 4) was obtained.The structures of all compounds were characterized by elemental analyses,NMR and MS.Atropisomerism was first found in compound 4 in CDCl3,and the proportion of different atropisomer(trans:cis) was calculated by 2D NMR.

Key words: atropisomerism, maleopimaric acid diimide, synthesis, conformation

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