Journal of Jishou University(Natural Sciences Edition)

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Urease Inhibition Evaluation of Sophora Flower Bud Extracts

YUE Qinqin,ZHANG Hongyu,YANG Meihui,XIE Meiqun,LI Qian,DENG Min,XIAO Zhuping   

  1. (1.College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,Hunan  China;2.Wulingshan Laboratory of Ethno-Medicine Engineering,Jishou 416000,Hunan China)
  • Online:2017-07-25 Published:2017-08-01


Urease inhibition of ethanolic,ethyl acetate and dichloromethane extracts from Sophora flower bud were evaluated through indophenol method.Results revealed good activities of the three extracts with IC50s of 2.63,1.90,0.53 g/L,respectively.Enzyme inhibition kinetics disclosed that these extracts showed reversible inhibition mechanism with mixed type,having Kis of 0.32,0.22,0.084 g/L,respectively.These findings provide a reasonable explanation for the stomach protection and restoration functions of Sophora flower bud.

Key words: Sophora flower bud, extract, urease, kinetics enzyme catalyzed reaction

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