Study on the Effect and Mechanism of Semen Raphani Oil in the Treatment of Chilblains

doi:10.13438/j.cnki.jdzk.2025.05.009

Abstract

Abstract: To investigate the anti-chilblain effect and mechanism of Semen Raphani oil,a mouse chilblains model was established to observe the effects of Semen Raphani oil on paw swelling rate,pain threshold,and pathological changes in chilblained tissues.Network pharmacology was used to explore the anti-chilblain components,targets,and signaling pathways of Semen Raphani oil.Animal experiments showed that Semen Raphani oil significantly alleviated paw swelling,increased the pain threshold in chilblained mice,relieved skin edema,and reduced the number of mast cells in chilblained tissues.Network pharmacology predictions indicate that Semen Raphani oil may interact with 38 potential targets in the treatment of chilblains.The core targets include MAOB,HSP90AB1,PTGS2,PTGS1,ACTB,MYC,PGR,NCOA2,RELA,and RXRA.The primary signaling pathways involved are neuroactive ligand signaling,chemical carcinogenesis-receptor activation,human cytomegalovirus infection,and the phosphatidylinositol-3-kinase-protein kinase B (PI3K-Akt) pathway.Key biological functions associated with these targets include smooth muscle contraction,xenobiotic stimulus response,and thermogenesis.

Key words: semen raphani oil, chilblains, mouse, mechanism

LEI Yan, JIN Shuo, DI Kaiyin, LIU Yuhui, YANG Ting, XIAO Ya, XU Da, WU Guanghui. Study on the Effect and Mechanism of Semen Raphani Oil in the Treatment of Chilblains[J]. Journal of Jishou University(Natural Sciences Edition), 2025, 46(5): 59-68.

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