Abstract: Objective:To Investigate the therapeutic effects and the prognosis of diffuse axonal injury(DAI).Methods:Seventy-five patients with DAI who were admitted to our department from Jan.1998 to Dec.2003 were  divided at random into two groups,the therapeutic group(n=35) and the control group（n=40）.The patients in the therapeutic group were suffered to the general therapeutic measures,combined with other measures including Nimodipine,Naloxone,moderate hypothermia and hyperbaric oxygenation.The patients in the control group were treated with the general therapeutic measures only.Results:According to the standards of GOS prognosis，the mortality rate of the patients in the therapeutic group(42.9%) was much lower than that of the patients in the control group(60%)，and the recovery rate of the therapeutic group patients(25.7%) was much higher than that of the control group patients(15%).There was significant difference in mortality and recovery rate between the two groups by X2 test(P<0.05).Conclusion:The therapeutic method of multi-measures may play the key role in improving the clinical outcomes for DAI,and it can significantly decrease the mortality of the patients with DAI．

Key words: diffuse axonal injury, therapy, prognosis