Journal of Jishou University(Natural Sciences Edition) ›› 2021, Vol. 42 ›› Issue (6): 48-53.DOI: 10.13438/j.cnki.jdzk.2021.06.008

• Medical Science • Previous Articles     Next Articles

Effect of LncRNA-ROR on the Hypoxia-Induced Gastric Cancer Metastasis and Invasion

ZHU Changming, SUN Gao, CHEN Gonghua, GONG Yugang, XIA Jie   

  1. (1.Department of Gastrointestinal Surgery, Zhangjiajie People's Hospital Affiliated to Jishou University, Zhangjiajie 427000, Hunan China; 2. School of Medical, Jishou University, Jishou 416000, Hunan China)
  • Online:2021-11-25 Published:2022-01-21

Abstract: Objective To investigate the effect of LncRNA ROR on metastasis and invasion in the hypoxia-induced invasion and metastasis in GC.Methods Using quantitative real-time polymerase chain reaction (RT-PCR) to detect the expression of ROR ingastric cancer tissues and cell lines.Employing the over-expression technique were used to observe the effect of overexpression of ROR on human gastric cancer cell metastasis and invasion, the transfection efficiency was verified by RT-PCR in SGC-7901 and MGC-803.Results ROR was significantly down-regulated in gastric cancer tissues samples compared with adjacent normal gastric tissues, and also down-regulated inthe hypoxic—induced GC cells. Hypoxia significantly increased the migration and invasion potential of SGC-7901 and MGC-803,After over-expression of ROR the hypoxia-induced migration and invasion of SGC7901 and MGC-803 cells were dramatically diminished. Conclusion LncRNA-ROR expression is decreased in hypoxic GC and suppressed hypoxia-induced GC metastasis and invasion, which could be a new biomarkers, a potential therapeutic target of gastric cancer.

Key words: gastric cancer, ROR, gastric cancer, metastasis and invasion

WeChat e-book chaoxing Mobile QQ