Effect of LncRNA-ROR on the Hypoxia-Induced Gastric Cancer Metastasis and Invasion

doi:10.13438/j.cnki.jdzk.2021.06.008

Abstract

Abstract: Objective To investigate the effect of LncRNA ROR on metastasis and invasion in the hypoxia-induced invasion and metastasis in GC.Methods Using quantitative real-time polymerase chain reaction (RT-PCR) to detect the expression of ROR ingastric cancer tissues and cell lines.Employing the over-expression technique were used to observe the effect of overexpression of ROR on human gastric cancer cell metastasis and invasion, the transfection efficiency was verified by RT-PCR in SGC-7901 and MGC-803.Results ROR was significantly down-regulated in gastric cancer tissues samples compared with adjacent normal gastric tissues, and also down-regulated inthe hypoxic—induced GC cells. Hypoxia significantly increased the migration and invasion potential of SGC-7901 and MGC-803，After over-expression of ROR the hypoxia-induced migration and invasion of SGC7901 and MGC-803 cells were dramatically diminished. Conclusion LncRNA-ROR expression is decreased in hypoxic GC and suppressed hypoxia-induced GC metastasis and invasion, which could be a new biomarkers, a potential therapeutic target of gastric cancer.

Key words: gastric cancer, ROR, gastric cancer, metastasis and invasion

ZHU Changming, SUN Gao, CHEN Gonghua, GONG Yugang, XIA Jie. Effect of LncRNA-ROR on the Hypoxia-Induced Gastric Cancer Metastasis and Invasion[J]. Journal of Jishou University(Natural Sciences Edition), 2021, 42(6): 48-53.

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