Journal of Jishou University(Natural Sciences Edition)

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Inhibitory Activity Screening of Extract from Lithocarpus Polystachyus Rehd. Against α-Glucosidase

FANG Hailian, LIU Meiling, LI Shiyao, XIAO Zhuping   

  1. (Hunan Engineering Laboratory for Analysis and Development of Ethnomedicine, Jishou University, Jishou 416000, Hunan China)
  • Online:2020-03-25 Published:2020-09-08


The inhibitory activity of extract from Lithocarpus polystachyus Rehd. against α-glucosidase has been researched. The extract was obtained through reflux extraction with different solvents and leaching with different polar solvents. By establishing α-glucosidase inhibitory model in vitro, the activity of extracts from the leaf of Lithocarpus polystachyus Rehd. was screened, and the relationship between inhibitory activity and concentration of the extract was researched. Results show that inhibition effect of methanol extract (IC50=34.30 mg/L) and n-butanol extract (IC50=30.47 mg/L) was closer to that of acarbose (IC50=25.26 mg/L).

Key words: Lithocarpus polystachyus Rehd., α-glucosidase, inhibitor, blood glucose

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