journal6 ›› 2012, Vol. 33 ›› Issue (6): 82-84.DOI: 10.3969/j.issn.1007-2985.2012.06.019

• Chemistry and chemical engineering • Previous Articles     Next Articles

Determination of Ranitidine in Drug Using Flow-Injection Chemiluminescence Method


  1. (School of Chemistry and Chemical Engineering,Anhui University of Technology,Ma’anshan 243002,Anhui China)
  • Online:2012-11-25 Published:2013-01-14

Abstract: A new chemiluminescence method for  determination of ranitidine is proposed.The method is based on the enhancement of ranitidine on the chemiluminescence reaction among cerium sulphate and sodium sulfite in H2SO4 medium.The linear relationship between the intensity of chemiluminescence and the concentration of ranitidine is in the range of 3.0×10-6~2.5×10-4 mol/L with the detection limit of 9.8×10-7 mol/L.The relative standard deviation is 3.3% for 11 measurements of 5.0×10-5 mol/L ranitidine standard solution.This method has been successfully applied to determination of ranitidine in injections and drug capsules with satisfactory results.

Key words: chemiluminescence, cerium sulphate, sodium sulfite, ranitidine

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