Study on the Inhibition Mechanism of 4-(4-Hydroxyphenethyl)Benzene-1,2-Diol on Urease

doi:10.3969/j.issn.1007-2985.2012.06.020

Abstract

Abstract: 4-(4-Hydroxyphenethyl)benzene-1,2-diol is a new inhibitor against Helicobacter Pylori urease.The inhibition mechanism was herein investigated through enzyme kinetics methods,and the results revealed that 4-(4-hydroxyphenethyl)benzene-1,2-diol was competitive inhibitor of urease with a Ki value of 1.48 μmol/L.The chemical stabilitiy and the competitive mechanism of 4-(4-hydroxyphenethyl)-benzene-1,2-diol strongly suggested that it could be used as a lead compound for rational drug design to find active compound and as a potential urease inhibitor for treatment of gastritis and peptic ulcer.

Key words: Helicobacter Pylori urease, 4-(4-hydroxyphenethyl)benzene-1,2-diol, enzyme kinetics, competitive inhibition

PENG Zhi-Yun, WANG Xu-Dong, FENG Yu-Ting, HE Juan, XIAO Zhu-Ping. Study on the Inhibition Mechanism of 4-(4-Hydroxyphenethyl)Benzene-1,2-Diol on Urease[J]. journal6, 2012, 33(6): 85-88.

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