Metabolic Dynamic of Camptothecin and 10-Hydroxycamptothecin in  Camptotheca acuminata Decne Leaves During the Process of Growth

Abstract

Abstract: An HPLC method for the simultaneous determination of CPT and HCPT in Camptotheca acuminata Decne.leaves was established.Using this assay,CPT and HCPT in leaves of Camptotheca acuminata Decne. in different seasons were determined.The results showed that，in a year,the content of CPT presented two peaks curve in tender leaves of C. acuminata,which appeared in July and September respectively and reached the highest point in July,while it declined persistently in older leaves;The accumulation of CPT and HCPT presented evident relativity in the different growth stages.

Key words: HPLC, leaves of Camptotheca acuminata, camptothecin, 10-hydroxy-camptothecin, growth stage

LI Xiang-Li, XIAO Kai-Jun, HU Xian-Yun, LUO Xin-Yi, GUO Si-Yuan. Metabolic Dynamic of Camptothecin and 10-Hydroxycamptothecin in Camptotheca acuminata Decne Leaves During the Process of Growth[J]. journal6, 2009, 30(5): 87-92.

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Metabolic Dynamic of Camptothecin and 10-Hydroxycamptothecin in Camptotheca acuminata Decne Leaves During the Process of Growth

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