journal6 ›› 2008, Vol. 29 ›› Issue (6): 104-106.

• Medical Science • Previous Articles     Next Articles

Effects of Astragaloside on Cardiomyocyte Apoptosis in Adriamycin-Induced Cardiomyopathy in Rats


  1. (Medical College of Jishou University,Jishou 416000,Hunan China)
  • Online:2008-11-25 Published:2012-05-19

Abstract: Objective  To explore the effects of Astragaloside on cardiomyocyte apoptosis and the expression of telomerase in adriamycin (ADR)-induced cardiomyopathy in rats.Methods  Male SD rats weighing about 250 g were used to establish the model of Adriamycin-induced Cardiomyopathy,then randomized into groups:Astragaloside group,ADR group,control group and control+Astragaloside group.Apoptotic cardiomyocytes were detected using the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling method (TUNEL).The expression of telomerase was determined by TRAP-PCR-ELISA method.Results  Compared with control group,ADR group had significantly higher index of apoptotic cardiomyocytes (P<0.05).The apoptotic index in Astragaloside group was less than that in ADR group (P<0.05),however significantly higher than that in control group and control+Astragaloside group (P<0.05).The expression of telomerase in Astragaloside group was significantly higher than that in ADR group(P<0.05),however significantly lower than that in control group and control+Astragaloside group (P<0.05).Conclusions  Myocardial apoptosis is an important mechanism of adriamycin-induced cardiomyopathy.Astragaloside therapy can inhibit cardiomyocyte apoptosis in adriamycin-induced cardiomyopathy,partly because it might increase expression of telomerase.

Key words: astragaloside, adriamycin, myocardium, apoptosis, telomerase

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