journal6 ›› 2007, Vol. 28 ›› Issue (2): 113-116.

• Medical Science • Previous Articles     Next Articles

Hypoxic Preconditioning Increases Expression of VEGF in the Hippocampus of Mice


  1. (1.Biology and Medicine Research Center,Baotou Medical College,Baotou 014010,Nei Monggol China;2.Institute for Hypoxia Medicine,Capital University of Medical Science,Beijing 100054,China;3.Department of Neurology,Taishan Medical College Affiliated Hospital,Taian 271000,Shandong China;4.Medical College of Jishou University,Jishou 416000,Hunan China)
  • Online:2007-03-25 Published:2012-06-18
  • About author:SHAO Guo(1972-),male,was born in Xiuyan County,Liaoning Province,associate professor,PhD,research area is molecular mechanism of hypoxia preconditioning.
  • Supported by:

    The National Natural Science Foundation of China (39670271);Beijing Natural Science Foundation (7962009)

Abstract: Objective:To detect the effect of hypoxia preconditioning on vascular endothelial growth factor (VEGF) expression in      acute repeated hypoxic mice hippocampus.Methods:Mice were divided into 3 groups randomly and were exposed to hypoxia for 4 runs (H4 group),1 run (H1 group) and  0 run (control group).Western Blot was used to examine the VEGF level in mice hippocampus following exposure to protein was extracted from mice hippocampus for Western blot.Results:VEFG were found in H0,H1 and H4 group.VEGF protein levels were found to be increased markedly in H4 (P<0.05,vs. H1 and H0).There is no difference between H1 and H0.Conclusion:The change of VEGF protein level is closely related to protection of the brain and the formation of preconditioning in hypoxic preconditioned mice.

Key words: hypoxic preconditioning, hippocampus, vascular endothelial growth factor

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