To study the correlation between cervical HPV infection and cervical intraepithelial and provide scientific reference basis for prevention, 692 patients in Xiangxi Autonomous Prefecture were randomly selected and received HPV-DNA test. 234 patients with positive result formed the observation group，and 234 patients with negative result formed the control group. Two groups of patients both got a cervical curettage by using colposcope. According to pathology, we divided all results into three parts: precancerosis (CINⅠ, CINⅡ, CINⅢ), cervical cancer and chronic cervicitis. The correlation between cervical HPV infection and cervical intraepithelia was analyzed by statistical software. Results showed that the major type of HPV infection in women of Xiangxi is HPV16 (26.54%), followed by HPV52, HPV51, HPV58, HPV18, HPV53.The increasing degree of CIN increased with HPV infection rate. Among CINⅠ, CINⅡ, CINⅢ, pairwise comparison was statistically significant. The HPV infection rate is 33.81%, and HR-HPV(+) infection rate was 31.74%; 21.97%, 11.99%, 1.88% were single, dual and multiple, and LR-HPV infection respectively. It is concluded that in screening for cervical cancer, clinical value of HR-HPV test should be highly regarded, and it is important to cut off HR-HPV infection in primary prevention of local women cervical cancer.