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Published in last 1 year |  In last 2 years |  In last 3 years |  All Please wait a minute... For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails Select Implications of  Self-Healing for the Research and Development of New Drugs and New Treatment Technologies for Diseases YANG Maosheng Journal of Jishou University(Natural Sciences Edition)    2024, 45 (6): 72-76.   DOI: 10.13438/j.cnki.jdzk.2024.06.011 Abstract （456）      PDF（pc） （628KB）（237）       Knowledge map    Save In order to explore a new path for research and development of new drugs and new treatment technologies for diseases,literatures relating to self-healing from Google Scholar,PubMed database,and Websites was retrieved and analyzed.It can be found that many human diseases show the possibility of self-healing.According to the above findings,a novel insight into developing new drugs and new treatment technologies for diseases is proposed based on triggering self-healing. Reference | Related Articles | Metrics | Comments（0） Select Development of a Useful Compound Functional Beverage with Eucommia ulmoides-Vinegar XIANG Xiaomei, FU Li, LI Xinyao, PENG Hongjin, HE Jianwu, CHEN Gongxi Journal of Jishou University(Natural Sciences Edition)    2024, 45 (6): 77-83.   DOI: 10.13438/j.cnki.jdzk.2024.06.012 Abstract （506）      PDF（pc） （5729KB）（122）       Knowledge map    Save The production process of the compound functional beverage of Eucommia Chinese black tea and rice vinegar was studied as the main raw materials.Design-Expert 8.0.6 was used to design the experiments and the sensory score of Eucommia ulmoides-vinegar used as the index to analyse the experimental data on the response surface.The results showed that the optimal formula of the Eucommia ulmoides-vinegar was the ratio of tea to water 4∶100（w∶w）,the addition amount of rice vinegar 2.28%,the addition amount of juice A 19.05%,and the addition amount of excipient B 7.76%.Under these conditions,the sensory score of Eucommia ulmoides-vinegar was the highest,reaching 88.4 points. Reference | Related Articles | Metrics | Comments（0） Select Establishment and Preliminary Application of Tail Suspension Analysis System Based on DeepLabCut LI Zhihong, SHENG Yihua, GU Xinli, ZHOU Cenfei, WANG Huizhi, JIA Zhujun, ZHANG Jianzhi, LI Sidi Journal of Jishou University(Natural Sciences Edition)    2024, 45 (6): 84-91.   DOI: 10.13438/j.cnki.jdzk.2024.06.013 Abstract （542）      PDF（pc） （1486KB）（835）       Knowledge map    Save A tail suspension analysis system has been established based on DeepLabCut (DLC) algorithm for evaluating depressive behavior in mice.Based on the DLC algorithm in deep learning technology,multi-path,semi-closed tail suspension hardware,the systems of software and hardware were constructed;this system and open field analysis system were applied to evaluate the tail suspension and open field behavioral changes in mice with reserpine depression model,intermittent alcohol consumption injury model,and periodontal silk ligation model.This system realized the synchronous analysis of head movement and limb movement in tail suspension,and automatically quantified 50 tail suspension indexes of dynamic and static type,posture type,and intensity type.It was found that in the reserpine depression model,compared with the control group,the movement distance,wall climbing times,and head swing times were reduced in the low-,medium-,and high-dose reserpine groups in 2 days,and the head swing times were reduced in the medium- and high-dose reserpine groups in 3 days and 4 days.In the intermittent alcohol consumption injury model,compared with the control group,the immobility time was reduced,the limb struggling times,movement distance,and movement time were increased in the low- and medium-dose ethanol groups,and the forelimb,hindlimb,and absolute struggling times were reduced in the high-dose ethanol group.In the periodontal silk ligation model,the movement distance and length,limb and absolute struggling times,and the total value of forelimb,hindlimb,and limb angles were reduced in the ligation group.Clearly,the DLC algorithm-based mouse tail suspension analysis system can accurately distinguish the behavioral characteristics of different mechanistic depression models. Reference | Related Articles | Metrics | Comments（0） Select Transformative Efficacy of Albumin-Bound Paclitaxel Combined with Tegafur,Gimeracil and Oteracil for Unresectable Pancreatic Cancer SONG Xin, ZHOU Guochao, YANG Dinghua, FU Hua, ZHOU Lyu, CAI Rongmin, TIAN Tanping Journal of Jishou University(Natural Sciences Edition)    2024, 45 (6): 92-96.   DOI: 10.13438/j.cnki.jdzk.2024.06.014 Abstract （516）      PDF（pc） （640KB）（113）       Knowledge map    Save In order to explore the efficacy and safety of albumin paclitaxel combined with tegafur (AS) regimen and albumin paclitaxel combined with gemcitabine (AG) regimen in the treatment of unresectable pancreatic cancer,patients with unresectable advanced pancreatic cancer who received AS regimen (24 cases) and AG regimen (16 cases) were selected as study subjects.Objective response rate,overall survival,progression-free survival and the incidence of grade 3/4 adverse reactions were compared between the two groups.The results showed that the objective response rate,median survival time and median progression-free survival time in AS group were higher than those in AG group,and there was no statistical significance between groups (P>0.05).The incidence of grade 3/4 peripheral nerve toxicity in AS group was significantly lower than that in AG group,and the difference was statistically significant (P<0.05).The incidence of grade 3/4 platelet count decrease,leukopenia,hemoglobin level decrease,infectious fever,nausea/vomiting,liver function impairment and poor appetite in AS group was lower than that in AG group,and the difference was not statistically significant (P>0.05).In the treatment of unresectable pancreatic cancer,the AS regimen has a lower risk of adverse effects. 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