Abstract: 45 pregnant rats were randomly divided into normal pregnant groups,model groups and Salvianolic acid B(Sal B)-treated groups.Pregnancy-induced Hypertension(PIH) rats model were induced by endotoxin infusing via caudal vein,and Sal B had been administered to the therapy groups at 22.5 mg·kg-1 per day.The blood pressure and 24 hours urine protein of three groups of rats were recorded every two days.All of the rats were killed;the number of fetal rats and the weight of placenta were measured on the 20th day of gestation.The results showed that blood pressure and 24 hours urine protein in Sal B-treated groups were obviously lower than those in model groups,the number of fetal rats was much more and the weight of placenta was heavier.So the research indicates that Sal B can be used to treat PIH.

Key words: Sal B, pregnancy-induced hypertension