Abstract: Fifty rats were randomly divided into normal group,model group,Colchicine group,high and low dose Euscaphis Japonica groups.Hepatic fibrosis models were established by CCl4 twice a week via intragastric administration for 8 weeks except normal groups.Colchicine (0.1 mg/kg) had been administered to the Colchicine group,water extracts from Euscaphis Japonica (1 mL/kg or 0.2 mL/kg) had been administered to the high and low dose Euscaphis Japonica groups from the fourth week. Five weeks later,all rats were killed to draw blood and separate serum,and  then all serum samples were analysed.The results showed that the  levels of HA,LN and PⅢP in the high and low dose Euscaphis Japonica groups were significantly lower than those in the model groups;there were no significant differences of HA,LN concentration between the high dose group and Colchicine group;and the level of PⅢP in high dose group was higher then that in Colchicine group but lower then in low dose group.It is concluded that water extracts from Euscaphis Japonica can be used to treat hepatic fibrosis in a dose-dependent manner.

Key words: water extracts from Euscaphis Japonica, hepatic fibrosis