Relationship Between Matrix Metalloproteinases and Atherosclerosis in Diabetics Mellitus

Abstract

Abstract: As a common chronic macrovalcular disease of diabetes mellitus (DM),Atherosclerosis (As) accounts for 80% mortality of DM.MMPs is knowed closely related to As in DM,and plays important roles in homeostasis of ECM,tissue remodelling and rehabilitating.High level of MMPs detected in diabetic patients with As suggests that MMPs may be important in the development and progressing of diabetic vascular disease.It would be helpful for preventing and restraining diabetic vascularopathy when targeting to decrease the level of MMPs.

Key words: diabetes mellitus, atherosclerosis, matrix metalloproteinases

SHA Yong-Hong, TANG Wei-Li. Relationship Between Matrix Metalloproteinases and Atherosclerosis in Diabetics Mellitus[J]. journal6, 2006, 27(5): 109-112.

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