Journal of Jishou University(Natural Sciences Edition) ›› 2021, Vol. 42 ›› Issue (6): 67-72.DOI: 10.13438/j.cnki.jdzk.2021.06.011

• Medical Science • Previous Articles     Next Articles

Effects of Atorvastatin on the Epilepsy Model of LI-PILO Rats

FENG Junxiang1, LI Jie   

  1. (1. Xinxiang Medical University, Xinxiang 453000, Henan China; 2. The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100,Henan China)
  • Online:2021-11-25 Published:2022-01-21

Abstract: Objective To study the neuroprotective effect of atorvastatin (ATV) on lithium pilocarpine chloride (LI-PILO) epilepsy model in SD rats. Methods  Induced status epilepticus (SE) model by intraperitoneal injection of LI-PILO, Record the behavioral changes of SD rats in the ATV group and the control group; Simultaneously use ELISA reagents and Nissl staining to detect serum inflammatory factor levels and neuronal damage in the chronic phase of the ATV group and the control group. Results  In the ATV group, serum inflammatory factors decreased significantly in the chronic phase, the SE Latency and Latent period of epilepsy were significantly prolonged, the level of seizures in the acute phase decreased significantly, and the spontaneous seizures in the chronic phase reduced significantly. Nissl staining showed that more neurons survived in the hippocampus. Conclusion  Atorvastatin may play a neuroprotective role by inhibiting the expression of inflammatory factors and reduce seizures in LI-PILO induced epilepsy model.

Key words: atorvastatin, epilepsy, inflammatory factors, neurons

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