Abstract: To observe the effect of salvia miltiorrhiza injection on CRP,P-sel and ICAM-1 in the blood of Type Ⅱ diabetic nephropathy patient and to approach the mechanism of conbined treatment of traditional Chinese medicine and Western medicine for the type Ⅱ diabetic nephropathy，salvia miltiorrhiza injection was applied to treat 38 patients with typeⅡ diabetic nephropathy,and  another 43 patients were used as contrasts  treated by routine Western  medicine.The content of CRP,P-sel and ICAM-1 in the blood of patients were detected both before and after the treatment.The results showed that the total effective rate of salvia miltiorrhiza injection treatment for type Ⅱ diabetic nephropathy was 68.4%,and that of the contrast group was 46.5%.There was significant difference between them.Before treatment the levels of CRP，P-sel and ICAM-1 between salvia miltiorrhiza injection group and Western medicine contrast group had no significant difference,but after treatment there was statistical difference between them,and the levels of CRP，P-sel and ICAM-1 molecule in the group cured by salvia miltiorrhiza injection were lower than that of contrast group.It can be concluded that there is significant curative effect of salvia miltiorrhiza injection treatment for type Ⅱ diabetic nephropathy patients.Probably the mechanism of treatment is that salvia miltiorrhiza injection can down regulate inflammatory cell activity and inhibite inflammatory reaction.

Key words: salvia miltiorrhiza injection, CRP, P-sel, intercellular adhesion molecule, type Ⅱ diabetic nephropathy