Abstract: This paper first analyzes the key techniques of the semi-conductor technology according to the physical features of the thermoelectric cooler （TEC）,and then provides the overall blue-print design of this system.The system adopts the closed-loop controlling system,which greatly strengthens the ability of disturbance resistance.The driving circuit,which is specially designed for the semi-conductor refrigerator can conveniently adjust the size and the direction，which passes through the TEC electricity so as to fully make use of the advantages of swift and quick refrigerating and heating.And the controlling method of PI makes the temperature control quick and stable.At the same time,the paper completes the mutual communication between temperature control equipment and computer by way of USB interface,so as to realize the remote control of computer to the temperature control equipment.

Key words: temperature control, peltier effect, semi-conductor cooler