journal6 ›› 2009, Vol. 30 ›› Issue (2): 125-128.

• Medical Science • Previous Articles    

On Teeth Mineralization of Hypophosphatasia


  1. (Pediatric Dentistry of Huaxi Stomatological Hospital,Sichuan University,Chendu 610000,China)
  • Online:2009-03-25 Published:2012-04-25

Abstract: Hypophosphatasia is an inherited disorder rarely known to dentists in China.Defective bone and teeth mineralization,deficiency of serum and bone alkaline phosphatase are typical features.Symptoms are highly variable,and premature loss of the teeth is the clinical manifestation for dentists to deal in time.The molecular pathogenesis,symptoms and therapy have been reviewed in the paper.

Key words: hypophosphatasia, tissue non-specific alkaline phosphatase, genetic mutation

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