journal6 ›› 2007, Vol. 28 ›› Issue (2): 82-86.

• Biological resources • Previous Articles     Next Articles

Physical Chemical Characters of Metabolites of Myxobacterium AHB125 and Bioactivities of Antitumor in Vitro


  1. (1.Department of Pharmaceutical,School of Biotechnology,Southern Yangtze University,Wuxi 214036,Jiangsu China;2.The Key Laboratory of Industrial Biotechnology,Ministry of Education,Southern Yangtze University,Wuxi 214036,Jiangsu China;3.Anhui Gujing Group,Bozhou 236820,Anhui China)
  • Online:2007-03-25 Published:2012-06-18

Abstract: Some physical chemical characters of metabolites of myxobacterium AHB125 isolated were introduced.Tumor cell lines models such as B16 and SGC7901 etc were applied to validate its bioactivity of methanol extracted dryness of myxobacterium AHB125 metabolited with MTT assay in vitro.Results showed that IC50 values of methanol elution dryness of myxobacterium AHB125 produced to tumor cell lines B16 and SGC7901 were 0.008 2 μg/mL and 0.036 μg/mL,respectively.And it showed high bioavtivity to Bel7402,H446,MCF-7 tumor cell lines,too.

Key words: myxobacteria, secondary metabolites, antitumor activity, IC50

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