Abstract: To optimize the extraction process of chlorogenic acid in flos lonicerae.several extraction processes were used respectively,i.e.,the refluxing method,the microwave method,the ultrasonic method,percolation method,decocting method and leaching method.The extracting solutions are methanol,ethanol,acetone,acetic ether,normal butand,water,acid water and chloroform.The optimum technology is acetone ultrasonic method,and the optimum extraction conditions were:10 fold of acetone,extracting 1 h,3rd time respectively.The content or chlorogenic acid and extraction rate were fairly high.The extracting rate is 8.46％,and the content of chlorogenic acid is 86.5％.

Key words: Flos Lonicerae, chlorogenic acid, extracting technology, extracting rate