Journal of Jishou University(Natural Sciences Edition)

• Medical Science • Previous Articles     Next Articles

Regulation of ATGL Activity and the Relation to Cardiac Hypertrophy

PENG Yingfu,GAO Hui   

  1. (Department of Pharmacology,School of Medicine,Jishou University,Jishou 416000,Hunan China)
  • Online:2016-09-25 Published:2016-10-01


Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of TG hydrolysis.There is high expression in adipose,liver,heart,and so on. ATGL knockout can result in bulks of triglyceride accumulation and induce significant cardiac hypertrophy in mice or rats. This review focuses on the regulation of ATGL activity and expression and how its dysfunction results in cardiac hypertrophy.

Key words: ATGL, triglyceride, cardiac hypertrophy

WeChat e-book chaoxing Mobile QQ