Abstract: Taking the vine tea from Xiangxi as the experimental raw material,we have optimized the extraction process of vine tea by single-factor experiments.The antibacterial activity and antioxidant activity of the vine tea extract were analyzed.The ratio of excipients in the prescription was further optimized to develop a vine tea extract lozenge.The quality of the product was tested to determine whether it met the relevant tablet quality standards.The results showed that the optimal extraction conditions were a solid-liquid ratio of 1∶40 (g∶mL),an ethanol volume fraction of 70%,a reflux time of 90 min,and a crystallization temperature of 10 ℃.The vine tea extract had a good inhibitory effect on Escherichia coli,with the maximum inhibition zone diameter being 15.1 mm.The vine tea extract had good scavenging abilities for hydroxyl radicals,superoxide anion radicals,and DPPH radicals,and also had a good reducing ability.Its radical scavenging level was much higher than that of citric acid and close to that of ascorbic acid.The preparation of lozenges employed a mixture of excipients consisting of 0.50 g dextrin,2.2 g starch,0.50 g sucrose,and 0.002 4 g magnesium stearate.The disintegration time of the finished product was 15 min,and the hardness,friability,appearance,and weight variation of the tablets all met the tablet quality standards of the Chinese Pharmacopoeia.

Key words: Xiangxi vine tea, dihydromyricetin, antibacterial activity, antioxidant, lozenge