Abstract: In order to explore the application effect of remimazolam combined with esketamine in tonsil or (and) adenoid surgery in children,children who planned to undergo tonsil or (and) adenoid resection were selected as study objects,and were randomly divided into observation group (given remimazolam combined with esketamine) and control group (given propofol combined with sufentanil).The mean arterial pressure,heart rate,FLACC score,Aono score,postoperative coughing,postoperative vomiting,extubation time and propofol addition before extubation were compared between the two groups.The results showed that the mean arterial pressure and heart rate during intubation and 5 min after intubation in observation group were higher than those in control group.The extubation time and the number of propofol addition before extubation in the observation group were significantly less than those in the control group.The FLACC score,Aono score,postoperative agitation rate and postoperative choking rate of the observation group were significantly lower than those of the control group,but the incidence of postoperative nausea and vomiting was not significantly different between the two groups.The application of remimazolam combined with esketamine in tonsillectomy or (and) adenoidectomy in children is effective,has stable hemodynamic characteristics,and helps to reduce the risk of perioperative hypotension,the incidence of postoperative adverse reactions,and further improves the recovery quality  of children.

Key words: remimazolam, esketamine, agitation during awakening, tonsillectomy