Abstract:

Mice treated with sucralfate and Fosson were used as animal model to test the therapy function of aqueous extract of different concentration (20，40，60 g/kg) from fern on constipation.Results showed that,compared with the sucralfate-treated group (negative control)，the groups treated with fern water extract displayed obvious therapy improvement on intestine propulsion (SIP)，first defecation time，faeces properties and 4 h defecation grain number and mass.On the other hand，compared with the Fosson-therapy group (positive control)，the middle dose group demonstrated almost the same effect on constipation therapy；but as for first defecation time，the high dose group treated with aqueous extract (（17.200 0±3.938 4）min)  was obviously sooner than the Fosson treated group (（26.800 0±3.881 6）min).And as for SIP，middle and low dose groups treated with fern aqueous extract (（34.000 5±6.057 5）%，（31.529 8±4.204 8）%) were obviously less than Fosson therapy group，but the high dose group (（41.9481±4.2194）%) showed almost no difference with Fosson therapy group（43.057 9±6.308 4）%).

Key words: Pteridium aquilinum, aqueous extract, constipation, therapy, mouse