Preparation and Characterization of Inclusion Complex Arteannuin with β-Cyclodextrin

doi:10.3969/j.issn.1007-2985.2013.04.016

Abstract

Abstract: The preparation and characterizations of the inclusion complex of arteannuin (ART) with β-cyclodextrin (β-CD) were investigated.The properties of arteannuin with β-cyclodextrin were characterized and analyzed by phase solubility analysis and infrared spectrography (IR).Results showed that β-cylcodextrin could increase the solubility of arteannuin;the inclusion constants of arteannuin with β-cylcodextrin (β-CD) was calculated as 77.44 L/mol;IR spectra showed that the intensity of a few characteristic absorption peak of ART decreased,the peak shape was widened and the displacement changed or disappeared under the influence of inclusion complex.It is concluded arteannuin and β-cylcodextrin can form stable inclusion complexes.

Key words: arteannuin, &beta, -cyclodextrin, inclusion complex, inclusion constant, infrared spectrum (IR)

TAN Qing-Hua, YANG Jiang-Jing, TANG Yan-Hui, DUAN You-Gou. Preparation and Characterization of Inclusion Complex Arteannuin with β-Cyclodextrin[J]. journal6, 2013, 34(4): 72-76.

References

[1] 杨阳.环糊精包合技术在药物制剂中的应用 [J].黑龙江科技信息,2011(7):63.

[2] 杨郁,张国梅,双少敏，等.环糊精包合作用及其分子识别功能的研究进展 [J].光谱实验室,2003,20(2):169-180.

[3] 雍国平,李光水,郑飞，等.β-环糊精包合物的结构研究 [J].高等学校化学学报,2000,21(7):1 124-1 126.

[4] 朱士龙,李勇,林卫红，等.青藤碱-环糊精包合工艺的优化及包合常数测定 [J].食品科学,2012,33(8):54-59.

[5] 朱士龙.青藤碱的稳定性及与环糊精包合物的性质分析 [D].吉首：吉首大学化学化工学院，2012.

[6] 朱士龙,陈迪钊,李勇，等.青藤碱-β-环糊精包合物的制备及表征 [J].中草药,2012,43(7):1 328-1 332.

[7] 肖作兵,吕翠翠,冯涛.β-环糊精/香精包合物研究进展 [J].粮食与油脂,2010(3):1-6.

[8] 杜鹏,张永萍.包合计术在药物研究中的应用 [J].贵阳中医学院学报，2008,30(6):62-64.

[9] 李金贵，朱奎.青蒿素包合物的表征及其对鸡球虫病的防治评价 [J].中国兽药杂志,2007,42(2):36-38.

[10] 刘静明,倪慕云,樊菊芳，等.青蒿素的结构和反应 [J].化学学报,1979,37(2):129-141.

[11] 王宗德,孙芳华.青蒿素理化性质及其测定方法的研究进展 [J].江西农业大学学报,1999,21(4):606-611.

[12] 刘春朝,王玉春,欧阳藩.青蒿素研究进展 [J].化学进展,1999,11(1):41-48.

[13] 刘春朝,王玉春,欧阳藩.青蒿素生物合成研究进展 [J].天然产物研究与开发,1999,12(1):83-86.

[14] 凌立新,张国芬,姚晨.青蒿素提取工艺研究 [J].亚太传统医药,2009,5(2):37-38.

[15] 吴慧,朱奎,李金贵,等.青蒿素-β-环糊精包合物的制备及鉴定 [J].黑龙江畜牧兽医,2006(12):94-95.

[16] 欧阳洋,楼紫阳,赵由才.紫外吸光度与渗滤液COD浓度的关系研究 [J].苏州科技学院学报,2003,16(3):6-10.

[17] 金小江,周建平.环糊精包合特性及包合常数的测定和预测 [J].药学进展,2005,29(11):491-497.

[18] 双少敏,郭祀远,潘景浩,等.相溶解度法测定β-环糊精-芦丁包合物的形成常数 [J].分析化学研究简报,1998,26(5):564-567.

[19] BENESI H A,HILDEBRAND J H.A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons [J].J. Am. Chem. Soc.,1949,71:2 703-2 707.

[20] 张叔良,易大年,吴天明.红外光谱分析与新技术 [M].北京：北京医药科技出版社,1993.