Abstract: Objective:To understand the features of children’s typhoid fever in the minority nationality region in Western Hunan.432 Methods:hospitalized children identified as typhoid fever were analyzed retrospectively.Results:All patients had fever and most of them were complicated with gastrointestinal tract symptoms.345 (79.86%) cases had hepatomegaly of which 86(19.90%) had splenomegaly,256 patients had complications including bronchitis-pneumonia (29.86%) hepatitis (14.8%) myocarditis (12.04%) and others.But rectal bleeding and intestinal perforation were seldom observed.White blood cell accounts were normal in (69.91%) children.Eosinophil accounts were decreased to zero in the major patients (79.86%).Antibiotics sensitive tests revealed that aminoglycosides,the third generation cephalosporins and Huroquinolones drags were sensitive to salmonella typhi chloramphenicol resistance to salmonella typhi decreased.Ampicillin and Compound Sulfamethoxazole resistance were common.Conclusions:Typhoid fever is present all year round but more prevalent in summer,and usually affects Children over 6 years of age.The clinical characteristics are atypical and complex.Zero of eosinophil accounts is still a major clue for typhoid fever.The third generation cephalosporins antibiotics show good effectivity in the treatment of children’s typhoid fever.

Key words: children；typhoid fever, minority nationality