Abstract: To evaluate plasma exchange of Artificial Liver Support Systems (abbreviated to ALSS) on Severe Hepatitis (abbreviated to SH).Method  30 patients with SH were estimated,undergoing plasma exchange of ALSS 51 times on the base of routine treatment.Analyze statistically the changes of their hepatic function,serum ammonia,prothrombin time (abbreviated to PT),platelet count (abbreviated to PC),etc.,before and after the therapy.Compare the cases to 31 controlled ones with SH who didnt receive ALSS before this technology being  applied in our hospital two years ago.Result  After the plasma exchange,the 30 cases got better hepatic function obviously.Many indexes were markedly improved,such as TBIL,DBIL,ALT,AST,serum ammonia,PT,PC and so on.Statistics analysis of them by U-test indicates remarkable contrast before and after the treatment (P<0.001).Meanwhile,it suggests significant differences between the two groups by performing x2-test for clinical curative rate,mending rate,and mortality rate (P<0.025).Conclusion  Plasma exchange on SH shows distinct shortdated theraputic effect.It can quickly eliminate excessive TBIL,ammonia etc.Coagulation factors reinforced betimes,thus bleeding tendency ameliorated soon.Mortality rate descended notably.Plasma exchange of ALSS is an important and effective measure and means great value on saving patients with SH.

Key words: artificial liver support systems, plasma exchange, severe hepatitis