Abstract: Objective To analyze the value of ultrasound-guided thick needle aspiration (US-CNB) histological examination in the diagnosis of early invasive lobular carcinoma (ILC) of the breast. Methods 169 patients with early breast cancer diagnosed in the breast surgery department of a third-class hospital in Wanbei, Anhui Province between October 2019 and October 2020 were selected as the research objects. Postoperative histopathological results (gold standard): early breast ILC 65 Cases, 104 other early breast cancer patients. All patients underwent ultrasound-guided fine-needle aspiration (US-FNAC) and US-CNB histological examinations before surgery, compared with postoperative pathological examination results, and recorded the value of US-FNAC and US-CNB in the diagnosis of early breast ILC, and all patients Comparison of the positive expression rates of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) tested by US-CNB. Results US-FNAC diagnosed 46 patients with early breast ILC and 123 other patients with early breast cancer. US-CNB diagnosed early breast ILC in 57 cases and 112 other early breast cancer patients. The sensitivity of US-CNB in diagnosing early breast ILC was 84.65% higher than that of US-FNAC 68.18% (P<0.05), but The accuracy and specificity of the two detection methods were not statistically significant (P>0.05); the positive expression rate of HER-2 in early breast ILC patients was higher than that in other early breast cancer patients (P<0.05), and the positive expression of ER and PR Compared with other early breast cancer patients, the rate was not statistically significant (P>0.05). Conclusion US-CNB histological examination has good sensitivity in diagnosing early breast ILC, and the positive expression rate of HER-2 in patients is high.

Key words: US-CNB histological examination, early invasive lobular carcinoma of the breast, diagnostic value