湘西藤茶提取物口含片的研制

doi:10.13438/j.cnki.jdzk.2025.05.012

摘要/Abstract

摘要：以湘西藤茶为实验原料，采用单因素试验优化藤茶的提取工艺,分析藤茶提取物的抑菌活性及抗氧化活性，进一步优化处方中的辅料配比，研制出一种湘西藤茶提取物口含片，并检验产品是否符合相关片剂质量标准.结果表明，最佳提取条件为料液比1∶40(g∶mL)、乙醇体积分数70%、回流时间90 min、结晶温度10 ℃；藤茶提取物对大肠杆菌的抑制效果良好，最大抑菌圈直径为15.1 mm；藤茶提取物具有良好的羟基自由基、超氧阴离子自由基、DPPH自由基清除能力，同时具有较好的还原能力，其清除自由基水平远超柠檬酸水平，接近抗坏血酸水平；口含片制备采用糊精0.50 g、淀粉2.2 g、蔗糖0.50 g和硬脂酸镁0.002 4 g的辅料配比，成品崩解时限为15 min左右，硬度、脆碎度、外观性状及片重差异等均符合《中国药典四部制剂通则》片剂质量标准.

关键词： 湘西藤茶, 二氢杨梅素, 抑菌活性, 抗氧化, 口含片

Abstract: Taking the vine tea from Xiangxi as the experimental raw material,we have optimized the extraction process of vine tea by single-factor experiments.The antibacterial activity and antioxidant activity of the vine tea extract were analyzed.The ratio of excipients in the prescription was further optimized to develop a vine tea extract lozenge.The quality of the product was tested to determine whether it met the relevant tablet quality standards.The results showed that the optimal extraction conditions were a solid-liquid ratio of 1∶40 (g∶mL),an ethanol volume fraction of 70%,a reflux time of 90 min,and a crystallization temperature of 10 ℃.The vine tea extract had a good inhibitory effect on Escherichia coli,with the maximum inhibition zone diameter being 15.1 mm.The vine tea extract had good scavenging abilities for hydroxyl radicals,superoxide anion radicals,and DPPH radicals,and also had a good reducing ability.Its radical scavenging level was much higher than that of citric acid and close to that of ascorbic acid.The preparation of lozenges employed a mixture of excipients consisting of 0.50 g dextrin,2.2 g starch,0.50 g sucrose,and 0.002 4 g magnesium stearate.The disintegration time of the finished product was 15 min,and the hardness,friability,appearance,and weight variation of the tablets all met the tablet quality standards of the Chinese Pharmacopoeia.

Key words: Xiangxi vine tea, dihydromyricetin, antibacterial activity, antioxidant, lozenge

倪德欣, 刘嘉旺, 尹光, 黄红君, 邹婧仪, 冯秋菊. 湘西藤茶提取物口含片的研制[J]. 吉首大学学报（自然科学版）, 2025, 46(5): 82-89.

NI Dexin, LIU Jiawang, YIN Guang, HUANG Hongjun, ZOU Jingyi, FENG Qiuju. Development of Xiangxi Vine Tea Extract Lozenges[J]. Journal of Jishou University(Natural Sciences Edition), 2025, 46(5): 82-89.

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