幽门螺杆菌基因多态性与致病性关系的研究进展

journal6 ›› 2009, Vol. 30 ›› Issue (3): 105-108.

幽门螺杆菌基因多态性与致病性关系的研究进展

(1.中南大学湘雅二医院消化科,湖南长沙 410011；2.吉首大学第一附属医院消化科,湖南吉首 416000)

出版日期:2009-05-25 发布日期:2012-04-23
作者简介:李学锋(1970-),男,湖南龙山人,吉首大学第一附属医院副主任医师,中南大学湘雅二医院博士生,主要从事消化系统疾病基础与临床研究.
基金资助:
湖南省卫生厅科研计划项目(B2007190)

Research Advancement of the Relationship Between Genic Polymorphism of Helicobacter Pylori and Pathogenicity

(1.Department of Gastroenterology,Second Xiangya Hospital,Centrer South University,Changsha 410011,China;2.Department of Gastroenterology,The First Affiliated Hospital,Jishou University,Jishou 416000,Hunan China)

Online:2009-05-25 Published:2012-04-23

摘要/Abstract

摘要：幽门螺杆菌感染是世界上最常见的人类细菌感染之一，其感染病灶主要集中在消化道.由于幽门螺杆菌是一组基因组结构变异很大的细菌，幽门螺杆菌基因碱基突变而产生的基因多态性使其不同基因型对不同消化系疾病的发病和临床结局产生不同影响.所以检测幽门螺杆菌基因多态性对发现幽门螺杆菌相关消化系疾病的易患人群和开展幽门螺杆菌的防治工作具有重要意义.文章综述了幽门螺杆菌基因多态性与消化病感染临床结局关系的研究进展状况.

关键词： 幽门螺杆菌, 基因多态性, 消化系疾病, 机制

Abstract: Hp infection is one of the most common bacterial infection in human being,and the digestive tract is the major part of Hp infection.The genome structure of Hp has much variation,so the mutation of Hp gene basic group causes genic polymorphism of Hp,and different gene types of Hp bring about different influences to morbidity and clinic outcomes of distinct digestive disease.Detection of genic polymorphism of Hp has important significance for discovery,prevention,and cure of the correlated disease of Hp.

Key words: Hp, genic polymorphism, digestive disease, mechanism

李学锋, 卢放根, 周明欢. 幽门螺杆菌基因多态性与致病性关系的研究进展[J]. journal6, 2009, 30(3): 105-108.

LI Xue-Feng, LU Fang-Gen, ZHOU Ming-Huan. Research Advancement of the Relationship Between Genic Polymorphism of Helicobacter Pylori and Pathogenicity[J]. journal6, 2009, 30(3): 105-108.

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