吉首大学学报(自然科学版) ›› 2025, Vol. 46 ›› Issue (1): 58-64.DOI: 10.13438/j.cnki.jdzk.2025.01.009

• 化学化工 • 上一篇    下一篇

负载型离子液体催化合成5-氨基-4-腈基-1,3-二苯基吡唑

文世悦,敖荣东,林世瑶,李培溪,张玉涛,胡玉林   

  1. (安顺学院化学化工学院贵州省高等学校农业资源与环境研究重点实验室,贵州 安顺 561000)
  • 出版日期:2025-01-01 发布日期:2025-01-20
  • 基金资助:
    国家自然科学基金资助项目(22368001);安顺学院SRT大学生科研训练计划项目(ASXYSRT202404);贵州省高等学校农业资源与环境研究重点实验室项目(黔教技[2023]025号);贵州省高等学校多孔材料与绿色催化创新团队项目(黔教技[2023]086号)

Study on Synthesis of 5-Amino-4-Nitrile-1,3-Diphenyl Pyrazole Catalyzed by Supported Ionic Liquid

WEN Shiyue,AO Rongdong,LIN Shiyao,LI Peixi,ZHANG Yutao,HU Yulin   

  1. (Key Laboratory of Agricultural Resources and Environment in High Education Institute of Guizhou Province,College of Chemistry and Chemical Engineering,Anshun University,Anshun 561000,Guizhou China)
  • Online:2025-01-01 Published:2025-01-20

摘要:设计并合成了一种负载型离子液体催化剂SiO2@IL,然后进行FT-IR,XRD,SEM,EDX分析,最后将其用于丙二腈、苯甲醛和苯肼的一步缩合反应中,以制备目标产物5-氨基-4-腈基-1,3-二苯基吡唑.实验结果表明,缩合反应的优化反应条件是以水为溶剂、催化剂用量0.3 g、反应温度45 ℃、反应时间3 h,此条件下的产物收率高达92%;在优化工艺条件下,催化反应过程可以放大至摩尔级;负载型催化剂相易从产物相中分离,可稳定地循环利用至少5次.该方法条件温和、后处理简单、产物收率高、工艺稳定,符合绿色化学的发展方向,具有良好的应用前景.

关键词: 负载型离子液体, 二氧化硅, 非均相催化, 5-氨基-4-腈基-1,3-二苯基吡唑

Abstract: In this study,a type of supported imidazolium ionic liquid SiO2@IL has been designed and synthesized.Its structure was analyzed by FT-IR,XRD,SEM and EDX.It was then applied to the one-step condensation reaction of malononitrile,benzaldehyde and phenylhydrazine to prepare the target product 5-amino-4-nitrile-1,3-diphenyl pyrazole.The results showed that the optimized reaction conditions for the condensation reaction were water as the solvent,0.3 g of catalyst,a reaction temperature at 45 ℃ and a reaction time for 3 h,under which the product yield was as high as 92%.Under the optimized process conditions,the catalytic reaction process could be scaled up to the molar level.The supported catalyst was easily separated from the product phase and could be stably recycled at least five times.This method had mild conditions,simple post-processing,high product purity,stable process,which meets the development direction of green chemistry and possesses good industrial application prospects.

Key words: supported ionic liquids, silicon dioxide, heterogeneous catalysis, 5-amino-4-nitrile-1,3-diphenyl pyrazole

公众号 电子书橱 超星期刊 手机浏览 在线QQ