自由基介导C—H键环化合成吲哚酮的研究进展

doi:10.3969/j.issn.1007-2985.2015.02.013

摘要/Abstract

摘要：吲哚酮及其衍生物广泛分布在自然界中，其合成方法研究是当前合成化学领域中的热点之一.按照偶联的方式及其相关的机理，对近几年来自由基介导C—H环化合成吲哚酮研究进行了归纳，从催化剂、氧化剂和溶剂等反应条件对反应体系的影响出发，讨论了C—H键的切断方法.

关键词： 自由基, C&mdash, H键氧化反应, 串联反应, 氧化反应

Abstract: Oxindole and its derivatives are widely distributed in nature,and the synthetic method has been one of the hot topics of synthetic chemistry.According to the coupling mechanism,the researches on oxindole synthesis through free radical mediated C—H cyclization in recent years are summarized.In view of the effects of catalyst,oxidizing agent,and solvent on the reaction system,this paper discusses the method of cleaving C—H bond.

Key words: free radical, C&mdash, H oxidation, tandem reaction, oxidant

周栋, 李玉花, 邓佑林, 李志豪 , 唐石. 自由基介导C—H键环化合成吲哚酮的研究进展[J]. journal6, 2015, 36(2): 60-70.

ZHOU Dong, LI Yu-Hua, DENG You-Lin, LI Zhi-Hao- , TANG Shi. Recent Progress on Radical C—H Bond Cyclization to Form Oxindoles[J]. journal6, 2015, 36(2): 60-70.

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