journal6 ›› 2013, Vol. 34 ›› Issue (4): 72-76.DOI: 10.3969/j.issn.1007-2985.2013.04.016

• 化学化工 • 上一篇    下一篇

青蒿素-β-环糊精包合物的制备及表征

  

  1. (吉首大学化学化工学院,湖南 吉首 416000)
  • 出版日期:2013-07-25 发布日期:2013-07-18
  • 通讯作者: 段友构(1954-),男,吉首大学化学化工学院教授,硕士生导师,E-mail duanyougou@126.com.
  • 基金资助:

    吉首大学研究性学习和创新性实验计划项目(2012ZXJJ06);湖南省教育厅资助项目(JG2011B041);湖南省普通高等学校教改项目(2012);吉首大学重点科研项目(201205-2)

 Preparation and Characterization of Inclusion Complex Arteannuin with β-Cyclodextrin

  1. (College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,Hunan China)
  • Online:2013-07-25 Published:2013-07-18

摘要:研究青蒿素-β-环糊精包合物的制备与性质,通过相溶解度法、红外光谱(IR)对其包合物进行表征.结果表明,β-环糊精可增加青蒿素的溶解度;相溶解度法测定青蒿素与β-环糊精的包合常数为77.44 L/mol;IR检测到青蒿素的特征吸收峰,受包合物形成的影响其强度降低、峰形变宽、发生位移或消失等现象,青蒿素与β-环糊精可以形成稳定的包合物.

关键词: 青蒿素, &beta, -环糊精, 包合物, 包合常数, 红外光谱

Abstract: The preparation and characterizations of the inclusion complex of arteannuin (ART) with β-cyclodextrin (β-CD) were investigated.The properties of arteannuin with β-cyclodextrin were characterized and analyzed by phase solubility analysis and infrared spectrography (IR).Results showed that β-cylcodextrin could increase the solubility of arteannuin;the inclusion constants of arteannuin with β-cylcodextrin (β-CD) was calculated as 77.44 L/mol;IR spectra showed that the intensity of a few characteristic absorption peak of ART decreased,the peak shape was widened and the displacement changed or disappeared under the influence of inclusion complex.It is concluded arteannuin and β-cylcodextrin can form stable inclusion complexes.

Key words: arteannuin, &beta, -cyclodextrin, inclusion complex, inclusion constant, infrared spectrum (IR)

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