核转录因子Relish的结构与功能研究进展

doi:10.13438/j.cnki.jdzk.2024.01.013

摘要/Abstract

摘要：核转录因子Relish是NF-κBs超家族中的一员，是重要的免疫信号传导效应物.Relish的N端有保守的Rel同源结构域，C端有锚蛋白重复结构域.受到外界各种刺激时由Imd通路传导信号，诱导Relish发生磷酸化、切割和其他翻译后修饰.活化的Relish进入细胞核与DNA结合调控靶基因表达，帮助生物体适应各种生理环境和刺激，抵御外来病原体入侵和感染.本文对Relish的结构与功能作了简要综述.Relish的结构主要包括Rel同源结构域、锚蛋白重复结构域、核定位序列、caspase靶位点、富含丝氨酸区域、富含脯氨酸-谷氨酸-丝氨酸结构域；Relish的功能主要有参与先天免疫、调节神经发育和寿命、调控肠道稳态和形态、参与压力调节及调节其他生理活动.

关键词： Relish, NF-κB, 先天免疫, Imd通路

Abstract: The nuclear transcription factor Relish is a member of the NF-κbs superfamily functioning as an important immune signaling effector.Relish contains a conserved Rel homologue domain at the N-terminal and an ankyrin repeat domain at the C-terminal.Relish is actived in response to certain external stimulations transmitted by the Imd pathway,via phosphorylation,cleavage and other posttranslational modification of Relish.Activated Relish then translocates to nuclear and binds to DNA to regulate the expression of target genes,helping organisms to adapt to various physiological environments and stimuli,resisting the invasion and infection of foreign pathogens.The paper provides an brief review of the structure and function of Relish.The structural features of Relish include Rel homology domain,ankyrin repeats domain,nuclear localization sequence,caspase target site,serine-rich regions,and proline-glutamate-serine-rich domain.Functions of Relish mainly involve participating in innate immunity,regulating neural development and lifespan,regulating intestinal homeostasis and morphology,participating in stress regulation and other physiological activities.

Key words: Relish, NF-κB, innate immunity, Imd pathway

张红, 刘青珍. 核转录因子Relish的结构与功能研究进展[J]. 吉首大学学报（自然科学版）, 2024, 45(1): 77-83.

ZHANG Hong, LIU Qingzhen. Research Progress of Structure and Function of Nuclear Transcription Factor Relish[J]. Journal of Jishou University(Natural Sciences Edition), 2024, 45(1): 77-83.

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