阿托伐他汀对LI-PILO癫痫大鼠模型的影响

doi:10.13438/j.cnki.jdzk.2021.06.011

吉首大学学报（自然科学版） ›› 2021, Vol. 42 ›› Issue (6): 67-72.DOI: 10.13438/j.cnki.jdzk.2021.06.011

阿托伐他汀对LI-PILO癫痫大鼠模型的影响

冯俊祥，李杰

(1.新乡医学院，河南新乡 453000；2.新乡医学院第一附属医院，河南卫辉 453100)

出版日期:2021-11-25 发布日期:2022-01-21
通讯作者: 李杰（1979—），男，山东曹县人，副主任医师，博士，主要从事难治性癫痫研究.
作者简介:冯俊祥（1993—），男，河南平舆人，主治医师，硕士研究生，主要从事难治性癫痫研究
基金资助:
新乡医学院第一附属医院科研基金项目（XYYFY2014BS-016）

Effects of Atorvastatin on the Epilepsy Model of LI-PILO Rats

FENG Junxiang1, LI Jie

(1. Xinxiang Medical University, Xinxiang 453000, Henan China; 2. The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100,Henan China)

Online:2021-11-25 Published:2022-01-21

摘要/Abstract

摘要：目的研究阿托伐他汀（ATV）对氯化锂-匹罗卡品（LI-PILO）癫痫SD大鼠模型是否具有神经保护作用.方法通过腹腔注射LI-PILO，建立LI-PILO诱导癫痫持续状态（SE）模型，记录ATV组和对照组SD大鼠的行为学变化；同时使用酶联免疫吸附测定法（ELISA法）和尼氏染色法检测ATV组及对照组SD大鼠在慢性期的血清炎症因子水平和神经元损伤情况.结果 ATV组SD大鼠的慢性期血清炎症因子明显下降，SE发作潜伏时间和癫痫潜伏期明显延长，急性期癫痫发作级别明显下降，慢性期自发性癫痫发作次数明显减少，尼氏染色结果显示ATV组SD大鼠的海马区有更多神经元存活.结论 ATV可能通过抑制炎症因子表达来发挥神经元保护作用，减轻LI-PILO诱导的癫痫SD大鼠模型中SD大鼠的癫痫发作症状和减少癫痫发作次数.

关键词： 阿托伐他汀, 癫痫, 炎性因子, 神经元

Abstract: Objective To study the neuroprotective effect of atorvastatin (ATV) on lithium pilocarpine chloride (LI-PILO) epilepsy model in SD rats. Methods Induced status epilepticus (SE) model by intraperitoneal injection of LI-PILO, Record the behavioral changes of SD rats in the ATV group and the control group; Simultaneously use ELISA reagents and Nissl staining to detect serum inflammatory factor levels and neuronal damage in the chronic phase of the ATV group and the control group. Results In the ATV group, serum inflammatory factors decreased significantly in the chronic phase, the SE Latency and Latent period of epilepsy were significantly prolonged, the level of seizures in the acute phase decreased significantly, and the spontaneous seizures in the chronic phase reduced significantly. Nissl staining showed that more neurons survived in the hippocampus. Conclusion Atorvastatin may play a neuroprotective role by inhibiting the expression of inflammatory factors and reduce seizures in LI-PILO induced epilepsy model.

Key words: atorvastatin, epilepsy, inflammatory factors, neurons

冯俊祥, 李杰. 阿托伐他汀对LI-PILO癫痫大鼠模型的影响[J]. 吉首大学学报（自然科学版）, 2021, 42(6): 67-72.

FENG Junxiang, LI Jie. Effects of Atorvastatin on the Epilepsy Model of LI-PILO Rats[J]. Journal of Jishou University(Natural Sciences Edition), 2021, 42(6): 67-72.

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阿托伐他汀对LI-PILO癫痫大鼠模型的影响

Effects of Atorvastatin on the Epilepsy Model of LI-PILO Rats

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