1例乳腺癌伴药物性肝损伤病例分析

doi:10.13438/j.cnki.jdzk.2022.05.014

吉首大学学报（自然科学版） ›› 2022, Vol. 43 ›› Issue (5): 89-92.DOI: 10.13438/j.cnki.jdzk.2022.05.014

1例乳腺癌伴药物性肝损伤病例分析

彭静，陈超，黎敏，徐幸民，宋奎，符一岚

（1.吉首大学第一附属医院药剂科，湖南吉首 416000；2.吉首大学第一附属医院血液科，湖南吉首 416000；3.湖南省肿瘤医院药学部，湖南长沙 410000)

出版日期:2022-09-25 发布日期:2023-01-11
通讯作者: 符一岚（1984—），女，湖南长沙人，湖南省肿瘤医院药学部主管药师，硕士，主要从事临床药学研究.
基金资助:
湖南省科技厅创新平台与人才计划项目（2021SK4050）彭静（1988—），女，湖南湘西人，吉首大学第一附属医院药剂科主管药师，硕士，主要从事临床药学研究

A Case Analysis of Breast Cancer Patient with Drug-Induced Liver Injury

PENG Jing,CHEN Chao,LI Min,XU Xingmin,SONG Kui,FU Yilan

(1.Department of Pharmacy,First Affiliated Hospital of Jishou University,Jishou 416000,Hunan China；2.Department of Hematology,First Affiliated Hospital of Jishou University,Jishou 416000,Hunan China；3.Department of Pharmacy,Hunan Cancer Hospital,Changsha 410000,China)

Online:2022-09-25 Published:2023-01-11

摘要/Abstract

摘要：通过对1例乳腺癌伴药物性肝损伤（DILI）患者的肝损伤情况、诊疗过程、用药情况进行分析，探讨DILI患者在抗肿瘤治疗过程中合适护肝药物的选择性问题，同时分析临床药师对DILI患者的药学监护作用，为同类患者顺利完成整个治疗周期提供参考

关键词： .临床药师, 药学监护, 药物性肝损伤

Abstract: By analyzing the conditions of liver injury,diagnosis and treatment process,medication for a case of breast cancer patient with drug-induced liver injury(DILI),selection of appropriate liver protective drugs in the process of anti-tumor treatment for DILI patients is explored,and the pharmaceutical care effect of clinical pharmacists on DILI patients is analyzed,which offers reference for the entire treatment cycle for similar cases.

Key words: clinical pharmacists, pharmaceutical care, drug-induced liver injury

彭静, 陈超, 黎敏, 徐幸民, 宋奎, 符一岚. 1例乳腺癌伴药物性肝损伤病例分析[J]. 吉首大学学报（自然科学版）, 2022, 43(5): 89-92.

PENG Jing, CHEN Chao, LI Min, XU Xingmin, SONG Kui, FU Yilan. A Case Analysis of Breast Cancer Patient with Drug-Induced Liver Injury[J]. Journal of Jishou University(Natural Sciences Edition), 2022, 43(5): 89-92.

参考文献

[1] 陈敬,刘芳群,曾建国,等.抗肿瘤药物致肝损伤患者的药学监护[J].中南药学,2016,14(9):1004-1008.
[2] MEIER YVONNE,CAVALLARO MARZIA,ROOS MALGORZATA,et al.Incidence of Drug-Induced Liver Injury in Medical Inpatients[J].European Journal of Clinical Pharmacology,2005,61(2):135-143.
[3] HUSSAINI SYED H,O’BRIEN CIARA S,DESPOTT EDWARD J,et al.Antibiotic Therapy:A Major Cause of Drug-Induced Jaundice in Southwest England[J].European Journal of Gastroenterology & Hepatology,2007,19(1):15-20.
[4] 国家卫生健康委员会.新型抗肿瘤药物临床应用指导原则(2018年版)[J].肿瘤综合治疗电子杂志,2019,5(1):35-54.
[5] 于乐成,茅益民,陈成伟.药物性肝损伤诊治指南[J].肝脏,2015,20(10):750-767.
[6] AKAY HAKAN,AKAY TUBA,SECILMIS SEMA,et al.Hepatotoxicity After Low-Dose Cyclophosphamide Therapy[J].Southern Medical Journal,2006,99(12):1399-1400.
[7] SUBRAMANIAM S RAVIH,CADER RIZNA ABDUL,MOHD ROZITA,et al.Low-Dose Cyclophosphamide-Induced Acute Hepatotoxicity[J].American Journal of Case Reports,2013,14:345-349.
[8] MCDONALD GEORGE B,MCCUNE JEANNINE S,BATCHELDER AMI,et al.Metabolism-Based Cyclophosphamide Dosing for Hematopoietic Cell Transplant[J].Clinical Pharmacology & Therapeutics,2005,78(3):298-308.
[9] CHALASANI NAGA P,HAYASHI PAUL H,BONKOVSKY,HERBERT L,et al.ACG Clinical Guideline:The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury[J].The American Journal of Gastroenterology,2014,109(7):950-966.
[10] 冯晓霞,梁海林,聂苑霞,等.药物性肝病发病机制研究进展[J].实用肝脏病杂志,2011,14(6):477-479.
[11] 房澍名,龚新雷,秦叔逵.新型甘草酸制剂防治抗肿瘤药物肝损伤的现状和进展[J].临床肿瘤学杂志,2013,18(9):833-841.
[12] 马军.血液病患者药物性肝损伤的预防和规范化治疗专家共识(2016年版)[J].中华血液学杂志,2016,37(6):441-452.
[13] 张亦琳,赵万红,张王刚,等.非霍奇金淋巴瘤化疗后脂肪肝形成临床研究[J].现代肿瘤医学,2018,26(24):4004-4007.
[14] 黄育华.特殊人群的药物性肝损伤[J].中西医结合肝病杂志,2019,29(1):1-6;96.
[15] 倪秀雄,姚琦,林秀珍,等.环磷酰胺致S180荷瘤小鼠肝损伤机制的实验研究[J].福建医药杂志,2004(2):93-94.
[16] TEMPLE ROBERT.Hy's Law:Predicting Serious Hepatotoxicity[J].Pharmacoepidemiology and Drug Safety,2006,15(4):241-243.
[17] REUBEN ADRIAN.Hy's Law[J].Landmarks in Hepatology,2004,39(2):574-578.
[18] LEWIS JAMES H."Hy's Law",the "Rezulin Rule",and Other Predictors of Severe Drug-Induced Hepatotoxicity:Putting Risk-Benefit into Perspective[J].Pharmacoepidemiology and Drug Safety,2006,15(4):221-229.
[19] 任军,周心娜.抗肿瘤药物肝损伤研究进展[J].中国药物应用与监测,2012,9(6):309-313.
[20] 秦叔逵,杨柳青,王科明,等.异甘草酸镁注射液预防抗肿瘤化疗相关性急性肝损伤的随机对照、全国多中心临床研究[J].临床肿瘤学杂志,2017,22(2):97-106.
[21] 李志强,夏春辉,王雅婧,等.异甘草酸镁注射液对比4种常用药物治疗药物性肝损害有效性与安全性的系统评价[J].中国药房,2015,26(33):4678-4681.
[22] 何梅,占美,柳汝明,等.还原型谷胱甘肽治疗药物性肝病的系统评价[J].中国药房,2010,21(32):3049-3052.

1例乳腺癌伴药物性肝损伤病例分析

A Case Analysis of Breast Cancer Patient with Drug-Induced Liver Injury

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