吉首大学学报(自然科学版) ›› 2022, Vol. 43 ›› Issue (5): 83-88.DOI: 10.13438/j.cnki.jdzk.2022.05.013

• 加工应用 • 上一篇    下一篇

一种医疗机构制剂的传统生产工艺

李进,罗远强,吴一振,彭勇,黄莉   

  1. (1.湘西土家族苗族自治州民族中医院,湖南 吉首 416000;2.湘西土家族苗族自治州人民医院,湖南 吉首 416000)
  • 出版日期:2022-09-25 发布日期:2023-01-11
  • 作者简介:李进(1981—),男,湖南保靖人,湘西土家族苗族自治州民族中医副主任药师,主要从事中药民族药制剂研究.
  • 基金资助:
    中国民族医药学会科研项目(2020MZ121-190701)

Study on Traditional Medicinal Preparation Technology of Jixiang Cough Ointment

LI Jin,LUO Yuanqiang,WU Yizhen,PENG Yong,HUANG Li   

  1. (1.Minzu Hospital of Xiangxi Tujia and Miao Autonomous Prefecture,Jishou 416000,Hunan China;2.Xiangxi Tujia and Miao Autonomous Prefecture People's Hospital,Jishou 416000,Hunan China)
  • Online:2022-09-25 Published:2023-01-11

摘要:建立一种使用传统工艺配制医疗机构制剂——吉祥止咳膏的生产工艺标准,饮片采用饮用水煎煮提取3次,时间依次为2 h,2 h,1 h,该条件下提取率(干浸膏)达96.21%.将3次提取液过滤后合并,置于低温热回流提取浓缩设备中浓缩得到相对密度1.15~1.25的清膏.称取适量冰糖加水熬制糖浆,糖浆沸腾时呈蜂窝状,在糖浆相对密度大于1.4(80 ℃)时加入清膏(清膏与糖浆质量比1∶1.5),常压收膏,浓缩成相对密度1.25~1.40的膏滋,添加0.1%山梨酸钾,灌装.吉祥止咳膏的煎煮提取、浓缩、炼糖、收膏等工艺与制剂室生产设备相适应,属于传统工艺配制的中药制剂,成品质量稳定,符合要求,可在医院制剂室生产;配制流程稳定简便、重现性好,是生产吉祥止咳膏的有效方法.

关键词: 传统工艺, 医疗机构制剂, 吉祥止咳膏, 水煎煮提取

Abstract: The standard for traditional medicinal preparation technology of Jixiang cough ointment has been established.The extraction rate (dry extract) reached 96.21% through three times of decoction with drinking water for 2 hours,2 hours,and 1 hour respectively.The extracts were filtered and combined for three times,and concentrated in the low-temperature hot reflux extraction and concentration equipment to obtain clear paste with a relative density of 1.15~1.25.A proper amount of rock sugar was boiled with water to make honeycomb-like syrup.When the relative density of syrup was greater than 1.4 (80 ℃),clear paste was added (the ratio of clear paste to syrup was 1∶1.5),and the paste was collected at normal pressure.The paste was concentrated with relative density 1.25~1.40,with addition of 0.1% potassium sorbate,and then was encapsulated.The extraction,concentration,sugar refining,paste collection,and paste collecting processes of Jixiang cough ointment are compatible with the equipments in the preparation room.It is a traditional Chinese medicinal preparation.The quality of the finished products is stable and meets the requirements,and it can be produced in the hospital preparation room.The preparation process is stable,simple,reproducible,and effective.

Key words: traditional technology, hospital preparations, Jixiang cough ointment, decoction

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