关键词： 铜催化, 脱氢偶联环化, 二叔丁基过氧化物, 含丙酮基吲哚酮

Abstract:

A highly efficient and simple synthesis way of copper-catalyzed carbonylation and cyclization  in active olefins to indole ketone was developed.At 100 ℃,the free radical tandem cyclization reaction with N-aryl acrylamides compounds synthesized a series of indole derivatives efficiently with cuprous chloride as a catalyst,di-tert-butyl peroxide (DTBP) as an oxidant and acetone as a solvent and reactant.We also explored the effects of different temperatures,catalysts,solvent and other factors on the reaction.Moreover,the mechanism of the cyclization reaction was derived.

Key words: copper catalysis, cyclization dehydrogenation coupling, di-tert-butyl peroxide, acetonylindolinone