流动注射化学发光法测定药物中的雷尼替丁

doi:10.3969/j.issn.1007-2985.2012.06.019

journal6 ›› 2012, Vol. 33 ›› Issue (6): 82-84.DOI: 10.3969/j.issn.1007-2985.2012.06.019

流动注射化学发光法测定药物中的雷尼替丁

(安徽工业大学化学与化工学院，安徽马鞍山 243002)

出版日期:2012-11-25 发布日期:2013-01-14
作者简介:吴芳辉（1976-），女，安徽六安人，安徽工业大学化工学院副教授，博士，主要从事功能材料的光电分析及应用研究.
基金资助:
安徽省教育厅自然科学重点基金资助项目（KJ2011A054）；安徽工业大学研究生创新研究基金资助项目

Determination of Ranitidine in Drug Using Flow-Injection Chemiluminescence Method

(School of Chemistry and Chemical Engineering,Anhui University of Technology,Ma’anshan 243002,Anhui China)

Online:2012-11-25 Published:2013-01-14

摘要/Abstract

摘要：在硫酸介质中，硫酸铈氧化亚硫酸钠产生微弱的发光信号，而雷尼替丁可显著增强该体系的化学发光，由此建立了流动注射化学发光技术测定雷尼替丁的新体系.实验结果表明，该方法的检出限为9.8×10^-7 mol/L，测定雷尼替丁的线性范围为3.0×10^-6~2.5×10^-4mol/L.对5.0×10^-5 mol/L雷尼替丁进行11次平行测定，其相对标准偏差为3.3%.将该方法用于药物胶囊中雷尼替丁的测定，结果令人满意.

关键词： 化学发光, 硫酸铈, 亚硫酸钠, 雷尼替丁

Abstract: A new chemiluminescence method for determination of ranitidine is proposed.The method is based on the enhancement of ranitidine on the chemiluminescence reaction among cerium sulphate and sodium sulfite in H₂SO₄medium.The linear relationship between the intensity of chemiluminescence and the concentration of ranitidine is in the range of 3.0×10^-6~2.5×10^-4 mol/L with the detection limit of 9.8×10^-7 mol/L.The relative standard deviation is 3.3% for 11 measurements of 5.0×10^-5 mol/L ranitidine standard solution.This method has been successfully applied to determination of ranitidine in injections and drug capsules with satisfactory results.

Key words: chemiluminescence, cerium sulphate, sodium sulfite, ranitidine

吴芳辉, 陈乐. 流动注射化学发光法测定药物中的雷尼替丁[J]. journal6, 2012, 33(6): 82-84.

WU Fang-Hui, CHEN Le. Determination of Ranitidine in Drug Using Flow-Injection Chemiluminescence Method[J]. journal6, 2012, 33(6): 82-84.

流动注射化学发光法测定药物中的雷尼替丁

Determination of Ranitidine in Drug Using Flow-Injection Chemiluminescence Method

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