丹酚酸B对妊高征大鼠的影响

journal6 ›› 2009, Vol. 30 ›› Issue (6): 115-117.

丹酚酸B对妊高征大鼠的影响

(吉首大学医学院药理教研室，湖南吉首 416000)

出版日期:2009-11-25 发布日期:2012-04-20
作者简介:高辉（1977-），男，安徽来安人,吉首大学医学院讲师，硕士，主要从事心血管药理学研究.
基金资助:
吉首大学校级课题及医学院资助项目（09JD020）

Effects of Salvianolic Acid B on Pregnancy-Induced Hypertension in Rats

(Department of Pharmacology,Medical College of Jishou University,Jishou 416000,Hunan China)

Online:2009-11-25 Published:2012-04-20

摘要/Abstract

摘要：目的研究丹酚酸B对妊高征的治疗作用.方法将45只妊娠后的大鼠随机分为正常妊娠组、模型对照组及丹酚酸B组，内毒素法造成妊高征模型，同时丹酚酸B组每日尾静脉注射丹酚酸B 22.5 mg/kg，给药期间各组大鼠每隔2 d测量血压及24 h尿蛋白量，妊娠第20天处死动物检查胎盘重量及孕鼠数.结果丹酚酸B组大鼠血压及24 h尿蛋白量明显低于模型对照组，胎盘明显重于模型对照组，孕鼠数也明显增多.结论丹酚酸B对妊高征有很好的治疗作用.

关键词： 丹酚酸B, 妊高征

Abstract: 45 pregnant rats were randomly divided into normal pregnant groups,model groups and Salvianolic acid B(Sal B)-treated groups.Pregnancy-induced Hypertension(PIH) rats model were induced by endotoxin infusing via caudal vein,and Sal B had been administered to the therapy groups at 22.5 mg·kg-1 per day.The blood pressure and 24 hours urine protein of three groups of rats were recorded every two days.All of the rats were killed;the number of fetal rats and the weight of placenta were measured on the 20th day of gestation.The results showed that blood pressure and 24 hours urine protein in Sal B-treated groups were obviously lower than those in model groups,the number of fetal rats was much more and the weight of placenta was heavier.So the research indicates that Sal B can be used to treat PIH.

Key words: Sal B, pregnancy-induced hypertension

高辉, 吕江明, 李春艳, 彭英福, 何玲. 丹酚酸B对妊高征大鼠的影响[J]. journal6, 2009, 30(6): 115-117.

GAO Hui, LV Jiang-Ming , LI Chun-Yan, PENG Ying-Fu, HE Ling. Effects of Salvianolic Acid B on Pregnancy-Induced Hypertension in Rats[J]. journal6, 2009, 30(6): 115-117.

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