质膜及其微区的蛋白质组学研究进展

journal6 ›› 2008, Vol. 29 ›› Issue (3): 97-104.

质膜及其微区的蛋白质组学研究进展

（1．南昌大学生命科学学院，江西南昌 330031；2．湖南师范大学生命科学学院,湖南长沙 410081）

出版日期:2008-05-25 发布日期:2012-05-23
通讯作者: 陈平(1962-),女,硕士生导师，主要从事生物化学研究.
作者简介:邓火保（1964-），男，江西彭泽人，硕士研究生，主要从事蛋白质化学和蛋白质组学研究;刘玮（1954-），男，硕士生导师，主要从事动物营养及消化生理学研究
基金资助:
国家自然科学基金资助项目（30770437）；湖南省科技厅重点资助项目（05FJ2002）

Progress in Proteomic Research of Plasma Membrane and its Microdomains

(1.College of Life Sciences,Nanchang University,Nanchang 330031,Jiangxi,China;2.College of Life Sciences,Hunan Normal University,Changsha 410081,Hunan China)

Online:2008-05-25 Published:2012-05-23

摘要/Abstract

摘要：质膜蛋白质由于低丰度和强疏水性等特点，给其提取、溶解、分离以及鉴定带来了很大的困难，因此使质膜蛋白质组学研究成为蛋白质组学研究中的难点和热点.以哺乳动物细胞质膜为例，主要从质膜及其微区的富集、溶解、分离、鉴定方法等方面介绍了细胞质膜及微区蛋白质组以及复合物的研究进展.

关键词： 质膜, 膜微区, 膜蛋白质组学, 膜蛋白质复合物

Abstract: Plasma membrane proteomic has become the difficulty and hot spot of proteomic research for its low abundance and strong hydrophobicity.With mammal cytoplasma membrane as an example,this article introduces the progress in proteomic research of plasma membrane and its microdomains mainly from the following aspects:the structure,concentrates,dissolution,separation and identification for plasma membrane and its microdomain as well as complex of membrane protein.

Key words: plasma membrane, membrane microdomains, plasma membrane proteomics, membrane protein complex

邓火保, 李选文, 刘玮, 陈平. 质膜及其微区的蛋白质组学研究进展[J]. journal6, 2008, 29(3): 97-104.

DENG Huo-Bao, LI Xuan-Wen, LIU Wei, CHEN Ping. Progress in Proteomic Research of Plasma Membrane and its Microdomains[J]. journal6, 2008, 29(3): 97-104.

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