粘细菌AHB125代谢产物的理化特征及其体外抗癌活性

journal6 ›› 2007, Vol. 28 ›› Issue (2): 82-86.

粘细菌AHB125代谢产物的理化特征及其体外抗癌活性

(1.江南大学生物工程学院生物制药系，江苏无锡 214036；2.江南大学教育部工业生物技术重点实验室，江苏无锡 214036；3.安徽古井集团，安徽亳州 236820)

出版日期:2007-03-25 发布日期:2012-06-18
通讯作者: 陶文沂，0510-85860721,wytao1946@163.com.
作者简介:郭文杰（1967-），男，安徽亳州市人，江南大学生物工程学院生物制药系博士研究生，主要从事生物制药研究.
基金资助:
国家自然科学基金资助项目(30770016)

Physical Chemical Characters of Metabolites of Myxobacterium AHB125 and Bioactivities of Antitumor in Vitro

(1.Department of Pharmaceutical,School of Biotechnology,Southern Yangtze University,Wuxi 214036,Jiangsu China；2.The Key Laboratory of Industrial Biotechnology,Ministry of Education,Southern Yangtze University,Wuxi 214036,Jiangsu China;3.Anhui Gujing Group,Bozhou 236820,Anhui China)

Online:2007-03-25 Published:2012-06-18

摘要/Abstract

摘要：介绍分离的粘细菌AHB125代谢产物的一些理化特征，并以小鼠黑色素瘤（B16）、人胃腺癌细胞（SGC7901）细胞株为模型，对粘细菌AHB125代谢产物的甲醇提取干燥物进行了体外活性试验，结果表明：其IC50分别达到了0.008 2 μg/mL和 0.036 μg/mL,并且对Bel7402、H446、MCF-7也表现出了极高的活性.

关键词： 粘细菌, 次生代谢产物, 抗癌活性, IC50

Abstract: Some physical chemical characters of metabolites of myxobacterium AHB125 isolated were introduced.Tumor cell lines models such as B16 and SGC7901 etc were applied to validate its bioactivity of methanol extracted dryness of myxobacterium AHB125 metabolited with MTT assay in vitro.Results showed that IC50 values of methanol elution dryness of myxobacterium AHB125 produced to tumor cell lines B16 and SGC7901 were 0.008 2 μg/mL and 0.036 μg/mL,respectively.And it showed high bioavtivity to Bel7402，H446，MCF-7 tumor cell lines，too.

Key words: myxobacteria, secondary metabolites, antitumor activity, IC50

郭文杰, 陶文沂, 毕芳, 董国秀. 粘细菌AHB125代谢产物的理化特征及其体外抗癌活性[J]. journal6, 2007, 28(2): 82-86.

GUO Wen-Jie, TAO Wen-Yi, BI Fang, DONG Guo-Xiu. Physical Chemical Characters of Metabolites of Myxobacterium AHB125 and Bioactivities of Antitumor in Vitro[J]. journal6, 2007, 28(2): 82-86.

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