ATGL生化功能调节及与心肌肥厚的关系

doi:10.3969/j.cnki.jdxb.2016.05.020

摘要/Abstract

摘要：

脂肪甘油三酯脂肪酶是脂肪分解代谢限速酶，ATGL广泛表达于全身各组织，尤其高表达于脂肪组织、肝脏和心脏等.ATGL敲除显示动物因大量甘油三酯堆积而产生严重肥胖，心脏受累尤其严重.主要介绍ATGL功能调节及其功能失调与心肌肥厚的关系

Abstract:

Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of TG hydrolysis.There is high expression in adipose，liver，heart，and so on. ATGL knockout can result in bulks of triglyceride accumulation and induce significant cardiac hypertrophy in mice or rats. This review focuses on the regulation of ATGL activity and expression and how its dysfunction results in cardiac hypertrophy.

Key words: ATGL, triglyceride, cardiac hypertrophy

彭英福，高辉. ATGL生化功能调节及与心肌肥厚的关系[J]. 吉首大学学报（自然科学版）, DOI: 10.3969/j.cnki.jdxb.2016.05.020.

PENG Yingfu,GAO Hui. Regulation of ATGL Activity and the Relation to Cardiac Hypertrophy[J]. Journal of Jishou University（Natural Sciences Edition), DOI: 10.3969/j.cnki.jdxb.2016.05.020.

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