journal6 ›› 2015, Vol. 36 ›› Issue (3): 90-93.DOI: 10.3969/j.cnki.jdxb.2015.03.019

• 生物资源 • 上一篇    下一篇

峨嵋双蝴蝶植物提取物的抗五步蛇毒作用

周罗琴,田宏现   

  1. (吉首大学生物资源与环境科学学院,湖南 吉首 416000)
  • 出版日期:2015-05-25 发布日期:2015-06-03
  • 通讯作者: 田宏现(1953—),男,湖南保靖人,吉首大学生物资源与环境科学学院教授,博士,主要从事微生物学和林业生物技术研究.
  • 作者简介:周罗琴(1987—),女,湖南邵阳人,吉首大学生物资源与环境科学学院硕士研究生,主要从事植物学研究

Antitoxic Effect of Extracts of Tripterospemum Cordatum Against  Deinagkistrodon Acutus Snake Venom

 ZHOU  Luo-Qin, TIAN  Hong-Xian   

  1. (College of Biology & Environmental Science,Jishou University,Jishou 416000,Hunan China)
  • Online:2015-05-25 Published:2015-06-03

摘要:研究峨嵋双蝴蝶植物水提物的抗五步蛇毒作用.建立小鼠五步蛇毒中毒模型,观察小鼠的中毒表现,并统计小鼠的死亡率,比较小鼠组织出血、组织坏死及组织溃疡状况.结果发现,峨嵋双蝴蝶植物水提物给药组动物的死亡率较模型组的明显下降,局部和全身症状较轻,而且随着剂量的增加症状显著减轻,尤其是对于组织的保护作用比较明显.峨嵋双蝴蝶植物水提物具有抗五步蛇毒作用,能降低蛇毒毒性.

关键词: 双蝴蝶提取液, 五步蛇, 抗毒性, 保护率

Abstract: The antitoxic effect of Tripterospemum cordatum aqueous extracts against Deinagkistrodon acutus snake venom is researched.The BACA/C mice were divided into five group according to the dosage of Tripterospemum cordatum aqueous extracts applied:low dosage,middle dosage,high dosage,blank group and model group,each group of health conditions being observed after 7-days intra-gastric administration.For the last time of administration,each group was intraperitoneally injected with Agkistrodon acutus snake venom after one hour later,then the mice’s poisoning performance was observed and the death rate was calculated,and each group of mice’s tissue bleeding,death and ulceration compared.The results showed that the aqueous extract of Tripterospemum cordatum at the low dosage,middle dosage and high dosage all reduced the mortality caused by Agkistrodon acutus snake venom poisoning and relieved some symptoms;with the increase of the dosage the symptoms decreased significantly,and the protection effect on the tissue was especially apparent.It can be concluded that the aqueous extract of Tripterospemum cordatum has antitoxic effect against Agkistrodon acutus snake venom and decrease the toxicity.

Key words: extracts of Tripterospemum, Deinagkistrodon acutus, antitoxic, protective rate

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