关键词： 黄花蒿, 药效物质基础, 黄酮化合物, 萜类化合物

Abstract: The pharmacodynamics substance in Artemisia annua L.was studied.The hemostasis chemical compositions were extracted by the organic solvent extraction method in Artemisia annua L..The hemostasis medicinal effect of the extract from Artemisia annua L.was detected using the coagulation plate method,the test tube method and the plasma recalcification time measurement method.The flavone compounds were separated from the butyl alcohol extract using Alkali dissolution-acid precipitation method.The spectroscopic properties were detected by the ultraviolet-visible spectroscopy and the fluorescence spectroscopy.And the flavone compounds were identified of the physical and chemical properties.The terpenoids compounds were separated from the butyl alcohol extract by the low temperature method,and were analyzed using the thin layer chromatography (TLC).The results indicated that the butyl alcohol extract was the hemostasis pharmacodynamics substance in Artemisia annua L..The clotting effect was significant of the butyl alcohol extract tested by the three methods of the coagulation plate method,the test tube method and the plasma recalcification time measurement method.And the chemical composition analysis showed that a lot of flavone compounds and the terpenoids compounds were contained in the butyl alcohol extract.It can be concluded that the pharmacodynamics substance is the butyl alcohol extract from Artemisia annua L.,and the major chemical constituents include the flavone compounds and the terpenoids compounds.

Key words: Artemisia annua L., pharmacodynamics substance, flavone compound, terpenoids compound