联合监测血清PCT，BNP，HBP水平变化对脓毒症患者早期诊断和预后评估的临床价值

doi:10.13438/j.cnki.jdzk.2021.06.010

吉首大学学报（自然科学版） ›› 2021, Vol. 42 ›› Issue (6): 62-66.DOI: 10.13438/j.cnki.jdzk.2021.06.010

联合监测血清PCT，BNP，HBP水平变化对脓毒症患者早期诊断和预后评估的临床价值

宋黎洁，王冉，陶言言

（蚌埠医学院第一附属医院，安徽蚌埠 233000）

出版日期:2021-11-25 发布日期:2022-01-21
作者简介:宋黎洁（1987—），女，蚌埠医学院第一附属医院主治医师，硕士，主要从事急诊危重症研究.
基金资助:
安徽省教育厅重点资助课题（KJ2019A0382）；蚌埠医学院自然科学重点资助项目（BYKY2019118ZD）

Clinical Value of Combined Monitoring of Blood PCT, BNP and HBP Levels in the Prognostic Evaluation of Patients with Sepsis

SONG Lijie, WANG Ran, TAO Yanyan

(First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui China)

Online:2021-11-25 Published:2022-01-21

摘要/Abstract

摘要：目的探究联合监测血清PCT，BNP，HBP水平变化对脓毒症患者早期诊断和预后评估的临床价值.方法根据治疗结局将100例患者分为治疗有效组（60例）和治疗无效组（40例），对受检者均实施单一监测（PCT，BNP，HBP）、两两联合监测（PCT+BNP、BNP+HBP、HBP+PTC）和PCT+BNP+HBP联合监测，分析比较两组患者的预后情况以及两组患者进行单一监测和联合监测的检出阳性率、敏感性和特异度.结果治疗有效组血清PCT（4.01±1.27）Pg/mL、BNP（61.41±1.27）Pg/mL及HBP水平（29.11±1.16）Pg/mL显著低于治疗无效组（P<0.05）；PCT+BNP+HBP联合检测检出阳性率、敏感度和特异性分别达98.00%，96.00%，92.00%，均明显高于单一监测和两项指标联合检测（P<0.05）.结论采用PCT+BNP+HBP联合监测，能对脓毒症患者进行有效早期诊断和预后评估.

关键词： 血清PCT, BNP, HBP, 联合监测, 脓毒症, 预后

Abstract: Objective To explore the clinical value of combined monitoring of blood PCT, BNP and HBP levels in the prognostic evaluation of patients with sepsis. Methods 100 patients with sepsis were selected as the subjects of this study, and the treatment period was from January 2020 to December 2020. All subjects were subjected to joint monitoring of changes in blood PCT, BNP and HBP levels, and the effect of the joint detection was analyzed. In order to clarify the effect. Results After the treatment of the patients, 100 patients were divided into 60 patients in the treatment improvement group and 40 patients in the treatment failure group according to the treatment outcome. The blood PCT (4.01±1.27) Pg/mL, BNP (61.41±1.27) of the treatment group was improved. ) Pg/mL and HBP levels (29.11±1.16) Pg/mL were lower than the treatment-ineffective group (P<0.05). The positive rate, sensitivity and specificity of the combined detection of the three indicators were 98.00%, 96.00%, and 92.00%, which were significantly higher than the single monitoring and combined detection of the two indicators, and the difference was statistically significant (P<0.05). Conclusion The combined monitoring of blood PCT, BNP and HBP levels can effectively evaluate the prognosis of patients with sepsis.

Key words: blood PCT, BNP, HBP, joint monitoring, sepsis, prognosis

宋黎洁, 王冉, 陶言言. 联合监测血清PCT，BNP，HBP水平变化对脓毒症患者早期诊断和预后评估的临床价值[J]. 吉首大学学报（自然科学版）, 2021, 42(6): 62-66.

SONG Lijie, WANG Ran, TAO Yanyan. Clinical Value of Combined Monitoring of Blood PCT, BNP and HBP Levels in the Prognostic Evaluation of Patients with Sepsis[J]. Journal of Jishou University(Natural Sciences Edition), 2021, 42(6): 62-66.

参考文献

[1] SHAHID W, NOMAN A, SIDRA S, et al. Shock Index as a Predictor of Hyperlactatemia for Early Detection of Severe Sepsis in Patients Presenting to the Emergency Department of a Low to Middle Income Country[J]. Journal of Ayub Medical College, Abbottabad: JAMC, 2020, 32(4): 465-469.
[2] METELMANN C, METELMANN B, GRNDLING M, et al. Vibrio Vulnificus, Eine Zunehmende Sepsisgefahr in Deutschland? Vibrio Vulnificus, an Increasing Threat of Sepsis in Germany[J]. Anaesthesist, 2020, 69(9): 672-678.
[3] 李艳,刘玲,裴依菲.凝血四项联合血清PCT、AT-Ⅲ、D-D水平监测在脓毒症患者病情评估中的应用价值[J].医药论坛杂志,2019,40(11):44-46.
[4] AKUOKU Y, HANSON R L, HARRIS D H, et al. Rapid and Simple Pressure-Sensitive Adhesive Microdevice Fabrication for Sequence-Specific Capture and Fluorescence Detection of Sepsis-Related Bacterial Plasmid Gene Sequences[J]. Analytical and Bioanalytical Chemistry, 2021, 413(4): 1017-1025.
[5] GUILLERMO K, ANA F, FRANCO D, et al. Recommendations for the Initial Management of Multisystem Inflammatory Syndrome Temporally Related to COVID-19, in Children and Adolescents[J]. Archivos Argentinos de Pediatría, 2020, 118(6): e514-e526.
[6] SUN Dahong, WANG Qing, ZHANG Xiaoyan, et al. Clinical Application of Serum Inflammatory Factors Combined with Dynamic Detection in the Diagnosis and Treatment of Neonatal Sepsis[J]. Iranian Journal of Public Health, 2021, 50(2): 325-332.
[7] 黄葵好,覃莎.血清PCT、NLR及外周血T淋巴细胞亚群与脓毒症患者预后的关系[J].中国医学创新,2019,16(20):37-40.
[8] VESNA V, IVA K, BRANKA D-, et al. Sepsis and Septic Shock: An Observational Study of the Incidence, Management, and Mortality Predictors in a Medical Intensive Care Unit[J]. Croatian Medical Journal, 2020, 61(5): 429-439.
[9] 梁群,张天宇,朱永志,等.化纤胶囊Ⅱ对气虚血瘀型脓毒症患者血清降钙素原白细胞计数及C-反应蛋白的影响[J].中国急救医学,2019,39(8):784-788.
[10] ASHER M, CASEY L, BRAEDON M, et al. 1229: National Preclinical Sepsis Platform: Multicenter Trials for Basic Science Research in Sepsis[J]. Critical Care Medicine, 2021, 49(1): 618-618.
[11] 何玲,肖晶,杨必彦,等.新生儿脓毒症休克血清AT与PCT、sh-CRP相关性及应用价值[J].昆明医科大学学报,2019,40(7):84-87.
[12] CONFIELD L R, BLACK G P, WILSON B C, et al. Vibrational Spectroscopic Analysis of Blood for Diagnosis of Infections and Sepsis: A Review of Requirements for a Rapid Diagnostic Test[J]. Analytical Methods, 2021, 14(2): 157-168.
[13] HENRY K E, CHANEY A M, NAGLE V L, et al. Demarcation of Sepsis-Induced Peripheral and Central Acidosis with pH (Low) Insertion Cycle Peptide[J]. J. Nucl. Med., 2020, 61(9): 1361-1368.
[14] 胡玲玲.重症肺炎合并脓毒症患儿血清PCT、Lac及内毒素的水平及意义[J].河北医药, 2019,41(15):2339-2341；2345.
[15] 付玉梅,王俊红,张冲,等.急诊重症多发伤患者合并早期脓毒症血清PCT、IL-6及CRP水平检测的临床价值分析[J].现代诊断与治疗,2019,30(10):1660-1661.
[16] 杜晓敏.加味防己茯苓汤联合CRRT疗法对脓毒症急性肾损伤患者肾功能及血清APN、PCT、Lac水平变化的影响[J].中国医药导刊,2019,21(3):152-156.
[17] MORRILL J H, KORMILITZIN A, NEVADO-HOLGADO A J, et al. Utilization of the Signature Method to Identify the Early Onset of Sepsis from Multivariate Physiological Time Series in Critical Care Monitoring[J]. Critical Care Medicine, 2020, 48(10): e976-e981.
[18] 张宇,徐云雷,刘连清.抗凝血酶Ⅲ与CRP联合PCT在脓毒症诊断中的应用价值[J].国际检验医学杂志,2019,40(23):2905-2908；2911.
[19] 杨晓梅,杭敏,许磊,等.脓毒症患者血清ESM-1、D-D、miR-155-5p、PCT的变化与患者预后的关系[J].医学临床研究,2019,36(4):759-761.
[20] 林应荣,罗玲玲,潘丹峰,等.脓毒症患儿血清超敏C-反应蛋白、可溶性髓样细胞触发受体-1、降钙素原的变化及意义研究[J].中国卫生检验杂志,2019,29(21):2647-2649；2652.

联合监测血清PCT，BNP，HBP水平变化对脓毒症患者早期诊断和预后评估的临床价值

Clinical Value of Combined Monitoring of Blood PCT, BNP and HBP Levels in the Prognostic Evaluation of Patients with Sepsis

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价